ESGLD Virtual Summer Meeting 28th – 30th June 2021- Final Programme details!!!
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Day 1 (Monday 28th June)
Welcome
12pm (BST)/1pm (CEST) Welcome introduction – Brian Bigger – ESGLD Chairman, UoM, Manchester, UK
Mechanisms of LSDs
Session 1 (Chair Eeva-Liisa Eskelinen)
12.10pm (BST)/1.10pm (CEST) Invited speaker
Carmine Settembre – TIGEM, Naples, Italy
Selective autophagy dysfunctions in lysosomal storage disorders.
12.45pm (BST)/1.45pm (CEST) Ulrich Matzner – Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but aggravates the disease phenotype of a mouse model of metachromatic leukodystrophy
1.05pm (BST)/2.05pm (CEST) Alessia Calcagni – CLN3 protein is at the crossroad between the biosynthetic/secretory compartment and lysosomes
1.25pm (BST)/2.25pm (CEST) Coffee break
Session 2 (Chair Fran Platt)
1.45pm (BST)/2.45pm (CEST) Invited speaker
Judith Klumperman – UMC Utrecht, Utrecht, Netherlands
The role of the HOPS complex in lysosomal biogenesis and diseases
2.20pm (BST)/3.20pm (CEST) Oriana Mandolfo – Systemic immune challenges exacerbate inflammation and cognitive decline in a mouse model of MPSIIIA
2.40pm (BST)/3.40pm (CEST) Lea Vidatic – BACE1 inhibition ameliorates neuroinflammation in organotypic brain slices of Niemann-Pick type C disease murine model
3pm (BST)/4pm (CEST) Coffee break
Session 3 (Chair Paul Saftig)
3.20pm (BST)/4.20pm (CEST) Invited speaker
Christian Haas – LMU Munich DZNE, Munich, Germany
Lysosomal dysfunction in microglia drives neuronal TDP-43 pathology in PGRN related FTLD
3.55pm (BST)/4.55pm (CEST) Antonietta Tarallo – Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease.
4.15pm (BST)/5.15pm (CEST) Selected abstract 6 Jose Clemente-Ramos – Using S. pombe to understand the pathogenesis of CLN3 disease
4.35pm (BST)/5.35pm (CEST) Group discussion on Mechanisms of LSDs (Chaired by Paul Saftig and Including Invited speakers from the day)
4.55pm (BST)/5.55pm (CEST) Day 1 main conference closes
5 – 5.30pm (BST)/6 – 6.30pm (CEST) Day 1 – Zoom Drinks Reception (Everyone Welcome – Bring Your Own Beer!) Meeting ID will follow
Day 2 (Tuesday 29th June)
Lysosomal Function
Session 1 (Chair Andrea Ballabio)
12pm (BST)/1pm (CEST) Keynote speaker
Juan Bonifacino – NIH, Bethesda, USA
Molecular mechanisms of lysosome positioning
Bright ideas/flash talks
12.35pm (BST)/1.35pm (CEST) S.L.M. in ‘t Groen – Uncovering pathological mechanisms in Pompe disease using a 3D-skeletal-muscle-on-a-chip system.
12.40pm (BST)/1.40pm (CEST) Mara Reichmann – Loss of TMEM55B leads to subfertility in male mice
12.45pm (BST)/1.45pm (CEST) Florian Bleimbaum – Co-expression network analysis identifies NHLRC3 as a new lysosomal protein to control endothelial cell homeostasis
12.50pm (BST)/1.50pm (CEST) Tereza Andreou – Brain-targeted Haematopoietic Stem Cell Gene Therapy for severe Mucopolysaccharidosis I (Hurler) – does one peptide tag fit all?
12.55pm (BST)/1.55pm (CEST) Jane Potter – Ex-vivo autologous haematopoietic stem cell gene therapy in mucopolysaccharidosis type IIIA
1pm (BST)/2pm (CEST) Q&A group discussion (Chair Andrea Ballabio)
1.20pm (BST)/2.20pm (CEST) Coffee break
Session 2 (Chair Mia Horowitz)
1.40pm (BST)/2.40pm (CEST) Invited speaker
Chiara di Malta – TIGEM, Naples, Italy
Transcriptional regulation of mTORC1 signaling in physiology and cancer
2.15pm (BST)/3.15pm (CEST) M Klussendorf – Cytoplasmic retention of acetylated transcription factor EB
2.35pm (BST)/3.35pm (CEST) Sonke Rudnik – S-palmitoylation determines TMEM55B-dependent positioning of lysosomes
2.55pm (BST)/3.55pm (CEST) Coffee break
Session 3 (Chair Thomas Braulke)
3.15pm (BST)/4.15pm (CEST) Invited speaker
James H. Hurley – University of California, Berkley, USA
Coordination of the Rag GTPase cycle on lysosomes
3.50pm (BST)/4.50pm (CEST) Dominic Winter – Characterization of Lysosomal Protein Interactions and Structures by Cross Linking Mass Spectrometry
4.10pm (BST)/5.10pm (CEST) Shroddha Bose – Impact of altered chloride transport on lysosomal morphology and function
4.30pm (BST)/5.30pm (CEST) Group discussion on lysosomal function (Chaired by Andrea Ballabio and Including Invited speakers from the day)
5.00pm (BST)/6.00pm (CEST) Day 2 main conference closes
5 – 5.30pm (BST)/6 – 6.30pm (CEST) Day 2 – Zoom Drinks Reception (Everyone Welcome – Bring Your Own Beer!) Meeting ID will follow
Day 3 (Wednesday 30th June)
Therapies and diagnosis
Session 1 (Chair Francisca Coutinho)
12pm (BST)/1pm (CEST) Invited speaker
Sandra Alves – Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA), Portugal
Oligonucleotide-based therapies for inherited metabolic diseases: some examples of their application in Lysosomal Storage Disorders.
12.35pm (BST)/1.35pm (CEST) Xuafeng Pan – Oral Glucosamine Ameliorates Aggravated Neurological Phenotype in Mucopolysaccharidosis III Type C Mouse Model Expressing Misfolded HGSNAT Variant
12.55pm (BST)/1.55pm (CEST) Atze Bergsma – Identification of aberrant splicing events that induce nonsense-mediated decay and development of splice switching antisense oligonucleotides for Pompe disease
1.15pm (BST)/2.15pm (CEST) Coffee break
Session 2 (Chair Pim Pijnappel)
1.35pm (BST)/2.35pm (CEST) Invited speaker
Federico Mingozzi – Spark Therapeutics, Philadelphia, USA
Targeting the liver to develop in vivo gene therapies for lysosomal storage diseases
2.10pm (BST)/3.10pm (CEST) Alessandro di Spiezio – Enzyme replacement therapy with pro cathepsin D in NCL disease
2.30pm (BST)/3.30pm (CEST) Valeria De Pasquale – Targeting heparin sulfate proteoglycans as a novel treatment for neuropathology in Mucopolysaccharidosis IIIB
2.50pm (BST)/3.50pm (CEST) Coffee break
Session 3 (Chair Brian Bigger)
3.10pm (BST)/4.10pm (CEST) Invited speaker
Eric Adler – UC San Diego, La Jolla, USA
New Therapy for Danon Disease (TBC)
3.45pm (BST)/4.45pm (CEST) Shaun Wood – Long-term Outcomes of Brain-targeted Haematopoietic Stem Cell Gene Therapy for Mucopolysaccharidosis Type II in Pre-Clinical MPSII Mouse Model
4.05pm (BST)/5.05pm (CEST) Nicola Brunetti – Safety and efficacy of liver-directed AAV-mediated gene therapy for mucopolysaccharidosis type VI
4.25pm (BST)/5.25pm (CEST) Group discussion on therapies and diagnosis (Chaired by Brian Bigger and Including Invited speakers from the day)
4.45pm (BST)/5.45pm (CEST) Coffee break
4.55pm (BST)/5.55pm (CEST) Award for best presentation
5pm(BST)/6pm (CEST) Award for best flash talk
5.05pm (BST)/6.05pm (CEST) Concluding remarks
5.10pm (BST)/6.10pm (CEST) Conference close