ESGLD… Welcome to the
News Archive Section
Here you will find articles about forthcoming and previous events, job vacancies, information regarding visiting scholarships and other assorted news items.
Save the Date - ESGLD Israel 2024 - Posted: August 2023
Save the Date – ESGLD Israel 2024
25th ESGLD Workshop and Graduate Course
3rd to 7th November, 2024
Save the date and join us in Israel!
Join us in Neve Ilan, Israel
ESGLD board membership election - Posted 6th February 2023
ESGLD board membership election:
With Andrea Ballabio and Eeva-Liisa Eskelinen both standing down from the board we have two places available. After asking for nominations from the membership the following two candidates were proposed and seconded.
Please read their info below and if you are happy with their candidacy vote for them to join the board, we have two places available so both Nicole and Nicolina will be welcome additions. Voting will close on the 7th February at Noon UK Time.
Nicole Maria Muschol
Nicole Muschol is a paediatrician and metabolic specialist. She is head of the lysosomal working group and spokeswoman of the International Center for Lysosomal Disorders (ICLD) at the University Medical Center Hamburg-Eppendorf in Germany. She is interested in basic science and clinical research, especially in MPS III and mucolipidosis and has been principal investigator or actively involved in many international clinical trials for lysosomal storage disorders.
Nicolina Cristina Sorrentino
Nicolina Cristina Sorrentino was graduated with honors in Biology Science at University of Naples “Federico II”. After working as fellow at the Telethon Institute of Genetics and Medicine of Naples (TIGEM), she started a PhD in “Life and biomolecular Sciences“ at Open University. Her main research interest is the development of new therapeutic strategies for the treatment of inherited neurodegenerative disorders.
In Memoriam: Prof. Dr. med. Michael Beck - Posted 1st November 2022
In Memoriam: Prof. Dr. med. Michael Beck
Prof. Dr. med. Michael Beck
Obituary – Georg Schetter
Shortly before this year’s Family Conference, we received the sad news that Prof. Dr. Michael Beck passed away unexpectedly on 6.9.2022.
Michael Beck would have been at the Family Conference as he has been for so many years. He would have taken part in the panel discussion this year, he would have had many conversations as always. Together we would have celebrated and we would have toasted his 75th birthday. All that has now turned out quite differently.
We have all been deeply affected by the unexpected death of Michael Beck. Many know Michael Beck because of his work as an outstanding physician – the “Villa Metabolica” will always be associated with his name – , as a teacher of many such wonderful doctors who are at our side today, and not least as a human being.
Today, so many things seem self-evident to us. There are therapies, new therapeutic approaches, an active research community and a vibrant MPS Society. In 1986, the year we were founded, things looked very different. Back then, there was nothing. Scientists and doctors had to be won over to deal with these so rare disease patterns, to do research and to develop therapies. Patient care had to be established and the enthusiasm of young doctors for metabolic diseases had to be awakened, as well as teaching had to be built up. Michael Beck has played a decisive and driving role in ensuring that an international community of scientists, doctors and MPS sufferers has dedicated itself to the topic of MPS. We cannot thank Michael Beck enough for this. Behind it all is not only a scientific and medical interest and a vocation. There is also an enormous private commitment behind it. For example, Michael Beck had a very special connection to us as the MPS Society, because he had been on the board of the MPS Society for many years in various positions since 1988.
It has affected us all deeply that Micheal Beck passed away so unexpectedly and so early. We have lost one of the great and important personalities of our German and international MPS community.
Dear Michael, we owe you so much. We miss you. You will always have a firm place in our community.
Yours, Georg, on behalf of the German MPS Society
In Memoriam: Prof. Dr. Eduard Paschke - Posted 1st November 2022
In Memoriam: Prof. Dr. Eduard Paschke
Prof. Dr. Eduard Paschke – 04.05.1949-14.07.2022
Obituary – Barbara Plecko – Silvija Tokic – Werner Windischhofer
Dear friends and colleagues,
It is with great sadness that, we wish to inform you that Prof. Eduard Paschke died unexpectedly of a heart attack on July 14th. We still can hardly believe his sudden death.
Eduard received his PhD in 1975 in clinical biochemistry in Prof. Hans Kresse ́s Lab at the Institute of Medical Chemistry in Graz, Austria. In 1979 he followed him to Münster where his research work focused on lysosomal metabolism. After returning to Graz in 1982 he founded the Laboratory of Metabolic Diseases at the Department of Paediatrics and Adolescent Medicine in close collaboration with Prof. Adelbert A. Roscher, Prof. Sylvia Stöckler and Prof. Wolfgang Erwa. From 1987 on he was the head of the research group for Biochemistry and Inborn errors of metabolism at our Children ́s University Hospital in Graz.
In the 1990s, Eduard made significant contributions to the molecular characterization of GM1 gangliosidosis versus Morquio B disease. For many years, actually decades, Eduard Paschke participated and contributed to the annual meeting of the Austrian MPS society, in collaboration and friendship with Michaela Weigl, Prof. Susanne Kircher and the MPS community. Eduard thus exemplified translational research long before this term was coined. He also had the foresight to implement genetic diagnostics and analytical techniques in the mid-nineties, along mass spectrometry for the determination of new biomarkers at our diagnostic laboratory in cooperation with Prof. Wolfgang Erwa and PD Günter Fauler. This enabled a comprehensive view of the individual patient’s phenotype, the metabolite pattern, residual enzyme activity and underlying genotype. His last active professional years until his retirement in 2014 he devoted to a joint research project with Prof. Tanja Wrodnigg and Prof. Arnold Stütz (Univ. of Technology Graz) on the development of
pharmacological chaperones as a mutation-specific therapy for lysosomal diseases. Concerning his employees, Eduard always had an open mind and heart as well as high social competence for the creation of new perspectives.
An unforgettable highlight of Eduard’s academic vita was the organization of the World MPS Conference in Vienna in 1999 together with Prof. Susanne Kircher and lastly the ESGLD Meeting in Seggau in 2013 as a farewell to the international LSD community.
As a private person Eduard was always in a good mood and very approachable. He preferred to spend the summers in his Greek adopted country, together with his beloved wife Dagmar and his three children and grandchildren. They have our deepest sympathy.
We will miss Eduard very much, not only in Graz, but certainly also in the circle of the Austrian working group for inborn errors of metabolism, and we will always honor his service to our department and to LSD patients and families. Eduard’s work in highly specialized lab-diagnostics and basic research will be continued with full enthusiasm by his successors and the whole team at our metabolic center.
On behalf of the entire Graz metabolism team,
Barbara Plecko, Silvija Tokic, Werner Windischhofer
24th ESGLD Workshop and Graduate Course … Quick Report - Posted 1st October 2022
24th ESGLD Workshop and Graduate Course
… Quick Report
We’ve had some great teachers,
we learnt a lot,
we scratched our heads a lot!
You had a flash talk task,
and little time to complete it,
“a bit” of stress,
but you all did a brilliant job!
We had excellent talks,
and some very democratic judges (!).
We explored caves, aqueducts,
and you made it to the castle somehow!
Some of you can still play ping-pong, pool and darts after a few drinks,
some of us not so good afterwards..
We made tons of new friends,
looking forward to new collaborations,
and who knows…
the DJ might still show up one day
It’s been a blast!
See you in 2024.
On behalf of the organising committee.
Thank you to Brian, Susannah, Laura, Stuart, Shaun, Fabio and Jan for contributing photos.
ESGLD are seeking… New Board Members… - Posted 1st September 2022
ESGLD are seeking…
New Board Members…
Dear ESGLD Members,
I hope you are all well and those who attended enjoyed our recent workshop and graduate course!
I am writing to inform you that two of our long standing board members have decided to step down and therefore we would like to invite the membership to propose new ESGLD board candidates. The plan will be to hold an AGM in December (date tbc) and ask the members to vote for their preferred candidates. If you have someone that you would like to propose please email firstname.lastname@example.org who will compile a list of candidates. It is essential that each candidate has a proposer and a seconder so please include both on your email.
The ESGLD Board would like to sincerely thank Prof. Eeva-liisa Eskelinen and Prof Andrea Ballabio for all their hard work on the board over the last few years.
I would also like to let the membership know that I have decided to step down as Chairman after 9 years in post. I will continue on the ESGLD board but feel it is time for a new chairperson to guide the group going forward. I will stay as caretaker chairman until a new chair is appointed.
Brian Bigger, ESGLD Chair
A Big Thank You - Posted 1st September 2022
A Big Thank You
We would like to say a big THANK YOU to everyone who participated in the recent 24th ESGLD Workshop and Graduate Course. It was great to have an in-person meeting again to discuss our science and meet old (and new) friends.
We would like to take this opportunity to congratulate our Prize Winners once again!
Best Oral Presentations:
Catarina Pechincha – The lysosomal enzyme trafficking factor LYSET enables nutrient generation from extracellular proteins.
Fabio Catalano – Brain targeting of GAA Promotes Full Correction of Murine Pompe Disease at a Clinically Relevant Dosage of Lentiviral Gene Therapy.
Edoardo Ratto – Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
Jan van der Beek – Loss of the HOPS complex induces hybrid early-late endosomes that accumulate endocytic, biosynthetic and autophagic cargo.
Best Flash talk groups exercise:
Catarina Pechincha, Drosos Katsavelis, Anastasia Laudicina
See you in Israel in 2024!
On behalf of the organising committee,
24th ESGLD Workshop and Graduate Course - Posted 1st June 2022
24th ESGLD Workshop and Graduate Course
BOOKINGS NOW OPEN…
Dear ESGLD members,
The ESGLD Chairman, Local Organising Committee and Scientific Committee are happy to announce that Registration and Abstract submission for the 24th ESGLD Workshop and Graduate Course to be held face to face in Lancaster, UK between 7th – 11th September 2022 is now open!!!
Key meeting dates:
7th – 8th September 2022: Graduate course
8th – 11th September 2022: 24th ESGLD workshop
Please go to www.esgld.org to check your lab membership (100 Euros) is up-to-date for the period 2022/2023 – this allows ALL members of your lab to register for the 24th ESGLD Workshop and Graduate Course.
For details of this event and to register and submit your abstracts please follow this link BOOK NOW
Abstract submission deadline is 1st August 2022 – go direct using this ABSTRACT SUBMISSION LINK.
For any queries about the 24th ESGLD Workshop and Graduate Course please contact: email@example.com
We look forward to seeing you there!
Please email Chairman for website enquiries, Treasurer for payment enquiries and Secretary for new membership enquiries.
24th ESGLD Workshop & Graduate Course – UK 7th-11th September 2022 - Posted 1st May 2022
24th ESGLD Workshop & Graduate Course – UK 7th-11th September 2022
Dear ESGLD Members, as you may know it is the turn of the UK to hold the Bi-Annual ESGLD Workshop and Graduate Course. ESGLD Chair, Professor Brian Bigger and his University of Manchester Team are happy to announce that a date has been set for this event which will take place in the Northwest of England. Please hold the 7th – 11th of September 2022 in your diaries!
Valuable Lysosomal Data made available again! - Posted 1st April 2022
Valuable Lysosomal Data made available again!
Original lysosomal membrane proteomics data accessible again
Dear ESGLD Members we are happy to let you know that the original data in the proteomics paper on human lysosomal membrane by Bernd Schröder et al. (Integral and Associated Lysosomal Membrane Proteins. Traffic Volume8, Issue12 December 2007, Pages 1676-1686) is now available again.
These data became inaccessible after Blackwell’s, the original publishing house of Traffic, had been discontinued, for quite a long time. Thanks to the efforts of editors with Willey, the present publisher of Traffic, all the original data are accessible again. Just click on “Supporting information” at the end of the paper, if you ever wished to see them and could not to.
There is extensive original data including sequence of more than 13 thousands identified peptides and various data evaluations that are available. Please see link HERE:
MPSII Clinical Trial Project Manager - Posted 1st February 2022
MPSII Clinical Trial Project Manager
University of Manchester are seeking to appoint a full-time Clinical Trial Project Manager to work on an academic gene therapy clinical trials for MPSII patients. The posts is available for an immediate start for a fixed term period for 3 years.
The position offers an ideal opportunity for an enthusiastic, well-motivated individual to work as part of a multi-disciplinary team to manage and ensure the success of this gene therapy clinical trial in MPSII patients. This CTIMP trial require an ambitious Project Manager to manage the set up and day to day running’s of the trial, liaising with the sponsor, clinical site, managing CRO and other third parties.
The post holder will also support the development of other new and ongoing clinical trials within the group and provide administrative support in the submission of industrial funding bids, grant applications and support the set up and running of a GCP facility. The post holder will have excellent interpersonal, communication, IT, and organisational skills, will be able to work with minimal supervision, and will have experience within research, preferably in biological or medical sciences within a trial setting. Adherence to good clinical practice (GCP) is essential to this role, particularly with regard to data handling and record keeping.
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
For further detail please follow link HERE:
Commemoration Meeting Prof. Milan Elleder – 5th October 2021 - Posted 1st September 2021
Commemoration Meeting Prof. Milan Elleder – 5th October 2021
A Commemoration meeting is to be held on the 5th of October 2021 to honour the memory of Professor Milan Elleder. It has been 10 years since he passed away. The meeting information is in the invitation – please click the link below.
There will be a Keynote lecture from Dr. Marie T Vanier (INSERM, Lyon, France) – Milan Elleder, the Prague group and Niemann-Pick diseases. It will be a good opportunity to meet to honour the memory of Professor Elleder the way we think he would like. The majority of the presentations are going to be in Czech but the Keynote lecture from Dr Vanier will be in English at 11:15-12:30 (CEST) and this is the link to the live stream (https://bit.ly/setkanielleder).
Milan Elleder was a key ESGLD figure for several decades and has contributed substantially to the community. Also, Marie Vanier´s keynote tribute to his contributions to understanding and delineation of NPA/B and NPC will be quite exceptional and of major interest to “lysosomalists” of all ages.
Also attached is Milan Elleder´s obituary that was written by Martin Hrebicek and was distributed to ESGLD members in 2011.
elleder_invitation (Link to event Invitation)
orbituaryElleder (Link to Obituary written by Martin Hrebicek)
MPSIIIA and MPSII Clinical Trial Project Manager Roles x 2 – deadline 6/10/21 - Posted 1st September 2021
MPSIIIA and MPSII Clinical Trial Project Manager Roles x 2 – deadline 6/10/21
University of Manchester are seeking to appoint two full-time Project Managers to work on two academic gene therapy clinical trials for either MPSII or MPSIIIA patients. The posts are both available for an immediate start for a fixed term period until the 30th October 2024.
The position offers an ideal opportunity for an enthusiastic, well-motivated individual to work as part of a multi-disciplinary team to manage and ensure the success of this gene therapy clinical trial in MPSII or MPSIIIA patients. Both trials require an ambitious Project Manager to manage the day to day runnings of the trial, liaising with the Sponsor, Clinical site, managing CRO and other third parties.
You will also support the development of other new and ongoing clinical trials within the group and provide administrative support in the submission of industrial funding bids, grant applications and support the set up and running of a GCP facility. The post holder will have excellent interpersonal, communication, IT, and organisational skills, will be able to work with minimal supervision, and will have experience within research, preferably in biological or medical sciences. Adherence to good clinical practice (GCP) is essential to this role, particularly with regard to data handling and record keeping.
For More information please follow this HERE:
ESGLD Virtual Summer Meeting – Thanks and Awards - Posted 1st September 2021
ESGLD Virtual Summer Meeting – Thanks and Awards
A big thanks to everyone who took part in our recent ESGLD Summer Virtual Meeting. We had a great turnout and a particular thanks to all our excellent speakers who made it such a success.
Talks over the three days covered a broad spectrum of topics including lysosomal function, mechanisms of lysosomal disease and therapies and diagnosis. The ESGLD Scientific Committee had the difficult task of choosing four outstanding presentations. Three prizes were awarded for the best presentations from the selected abstracts and one prize for the best flash talk.
Awards for best selected abstract presented to:
Alessia Calcagni (Baylor College of Medicine ) – CLN3 protein is at the crossroad between the biosynthetic/secretory compartment and lysosomes
Malte Klüssendorf (University Medical Center, Hamburg-Eppendorf) Cytosoplasmic retention of acetylated transcription factor EB
Dominic Winter (University of Bonn) Characterization of Lysosomal Protein Interactions and Structures by Cross Linking Mass Spectrometry
Award for best Flash Talk/Virtual Poster presented to:
S.L.M. in ‘t Groen (Erasmus MC) – Uncovering pathological mechanisms in Pompe disease using a 3D-skeletal-muscle-on-a-chip system.
For further information please contact:
Nicolina Cristina Sorrentino, PhD
Telethon Institute of Genetics and Medicine
Via Campi Flegrei 34
80078 Pozzuoli (NA), Italy
Phone: +39 081 1923 0649
Fax: +39 081 1923 0651