24th ESGLD Workshop and Graduate Course

7th to 11th September 2022

SAVE THE DATE!  As you may know it is the turn of the UK to hold the Bi-Annual ESGLD Workshop and Graduate Course. ESGLD Chair, Professor Brian Bigger and his University of Manchester Team are happy to announce that a date has been set for this event which will take place in the North West of England. Please hold the 7th to 11th of September 2022 in your diaries!

About the Venue

Lancaster…  Successful conferences start with a tailor-made conference facility.

Our dedicated venue provides the variety, flexibility and services to meet the demands of all sorts of conferences, meetings or training courses.

We have three large suites, each with room for 100 guests, together with a selection of meeting rooms, breakout areas and a light, open foyer area that’s perfect for registration or welcome sessions.

However, our Conference Centre is more than a selection of spaces. Here you’ll find the technology for engaging presentations, the catering service for tasty meals and refreshing breaks, and all the professional support and events expertise to plan, manage and host the best possible conferences.

Local Organising Committee:

Brian Bigger, Manchester | Chair
Tereza Andreou, Manchester
Laura Booth, Manchester
Stuart Ellison, Manchester
Susannah James, Manchester
Shaun Wood, Manchester

International Organising Committee:

Brian Bigger, UK
Andrea Ballabio, Italy
Francisca Coutinho, Portugal
Simon Jones, UK
Nicole Muschol, Germany
Paul Saftig, Germany

ESGLD 2022 Faculty

Brian Bigger

Brian Bigger

ESGLD Chairman, University of Manchester, UK

Brian Bigger was awarded a Bachelors degree from the University of Bath in Applied Biology. His PhD was conducted in the Gene Therapy Research Group, Imperial College, London, where he worked with Professor Charles Coutelle on developing a gene delivery vehicle for mitochondrial gene therapy. On completion of his PhD in 2000, Dr Bigger joined Dr Mike Themis, Imperial College, London to work on a Wellcome Trust collaborative project with Cancer Research UK, investigating gene delivery to stem cells for liver diseases. In 2004 he joined Dr Suzanne Watt’s group in Oxford University and the National Blood Service as a Senior Research Scientist to work on mechanisms of stem cell homing. In 2006 Dr Bigger set up the Stem Cell & Neurotherapies laboratory at the University of Manchester and the Royal Manchester Children’s hospital.

Markus Damme

Markus Damme

Christian-Albrechts-University, Kiel, Germany

Markus Damme studied biology at the University of Göttingen and started his work on lysosomes and lysosomal storage diseases already with his Diploma studies. After obtaining the diploma, he did his PhD at the Department of Biochemistry in Göttingen in 2009. After a short PostDoc in Göttingen, he moved to Bielefeld University for another PostDoc, and started in 2013 his work in the Biochemical Institute at the Christian-Albrechts-University in Kiel. In Kiel he became a group leader and is still working in at the Biochemical Institute as an assistant professor. Markus Damme has published >60 peer reviewed papers mostly focused on lysosomal proteins, lysosomal biology and autophagy.

Andrea Ballabio

Andrea Ballabio

TIGEM, Federico II University, Naples Italy

Andrea Ballabio obtained his M.D. degree and residency in Pediatrics at the University of Naples, Italy. After working as post-doctoral fellow at the Institute of Genetics and Biophysics in Naples and at Guy’s hospital in London UK, he moved to the Department of Molecular and Human Genetics of Baylor College of Medicine in Houston TX USA, where he became Associate Professor and Co-director of the Human Genome Center. In 1994 he moved back to Italy to become the founding director of the Telethon Institute of Genetics and Medicine (TIGEM). He is currently Professor of Medical Genetics at the University of Naples “Federico II” and Visiting Professor at Baylor College of Medicine in Houston, Texas. He was two-time winner of the Advanced European Research Council (ERC) 5 year-grant and winner of the 2106 Louis-Jeantet prize for Medicine. His current roles are: Director and Founder of the Telethon Institute of Genetics and Medicine (TIGEM) and Professor of Medical Genetics, Federico II University, Naples Italy and Visiting Professor, Department of Molecular and Human Genetics, Ian and Dan Duncan Neurological Research Institute, Houston TX USA, Co-Founder of CASMA Therapeutics, Advisory Board Member of Next Generation Diagnostics and Avilar Therapeutics. He has authored over 350 publications in international peer-reviewed journals.

Paul Saftig

Paul Saftig

Biochemical Institute at the University Kiel, Germany

Paul Saftig, Biochemical Institute at the University Kiel is director of the department. He is chairing a group of scientists working at projects aiming to understand the functions of lysosomes and their role in health and disease. There is a focus to decipher the (patho)physiological role of membrane components of the lysosomal compartment. Approved therapies for lysosomal storage disorders including alpha-mannosidosis were developed in the lab. New trafficking routes to the lysosomal compartment were discovered. The role of lysosomal proteins and different types of membrane-associated proteases in more common neurodegenerative disorders like Alzheimer Disease and Parkinson Disease are addional topics of interest. Dr. Saftig´s work has been presented in about 300 original publications and review articles in highly recognized scientific journals. Dr. Saftig received the highest German Alzheimer Research Award (2011) and the EU-Horizon Impact Award (2019). Dr Saftig has chaired a number of national and European research networks.

Volkmar Gieselmann

Volkmar Gieselmann

University of Bonn, Germany

Volkmar Gieselmann studied Medicine in Frankfurt and Münster. After his graduation he was a postdoc at the Institute of Biochemistry at the University of Münster where he joined the group of Kurt von Figura. Subsequently he worked as an MD in the Department of Hematology and Oncology of the University of Münster. After a post doc at the Harvard Medical School Department of Genetics joined again the group of Kurt von Figura now at the University of Göttingen. In 1992 he received a Heisenberg-fellowship and an endowed professorship of the Herman and Lilly Schilling foundation. In 1994 he was appointed Professor of Biochemistry at the University of Kiel and since 1999 he is full professor of biochemistry at the University of Bonn. In 2008 he received the Rare Disease Research award of the Eva-Luise and Horst Köhler foundation. He has a long-standing interest in lysosomal storage disorders, in particular in metachromatic leukodystrophy. He has cloned the defective gene in this disease and developed the respective animal models in which he performed a number of preclinical studies. He has been a member of the Board of Directors of the University of Bonn from 2009-2015 and for 8 years Chairman of the European Study Group on Lysosomal Diseases (ESGLD) until 2015.

Jan van der Beek

Jan van der Beek

UMC Utrecht, Netherlands

Jan van der Beek is a cell biologist and microscopist. Life-long curiosity and BSc and MSc degrees in Biology at Utrecht University shaped his passion for cell biology. He gained interest and experience in advanced microscopy during internships in the labs of Anna Akhmanova (Utrecht University) and Jonas Ries (EMBL). In his PhD in the lab of Judith Klumperman (UMC Utrecht), electron microscopy was the next challenge and addition to Jan’s expertise in cellular imaging. Currently, Jan combines different microscopic methods to study the internal organization of cells. His research focuses on the endo-lysosomal system and the role of the lysosomal tethering complex HOPS in regulation of endo-lysosomal processes. As a PostDoc in the lab of Judith Klumperman, he aims to elucidate the role of the HOPS complex in lysosomal fusion as well as in trafficking of lysosomal membrane proteins

Nicole Maria Muschol

Nicole Maria Muschol

University Medical Center Hamburg-Eppendorf, Germany

PD Dr. Nicole Maria Muschol is a paediatrician and metabolic specialist. She is head of the lysosomal working group and spokeswoman of the International Center for Lysosomal Disorders (ICLD) at the University Medical Center Hamburg-Eppendorf in Germany. She is interested in basic science and clinical research in particular in MPS III and has been principal investigator or actively involved in many international clinical trials for lysosomal storage disorders.


David Rubinsztein

David Rubinsztein

University of Cambridge, UK

David Rubinsztein is Professor of Molecular Neurogenetics and a UK Dementia Research Group Leader at the University of Cambridge. He is Deputy Director of the Cambridge Institute for Medical Research and Interim Director of the UK Dementia Research Institute at the University of Cambridge. Dr. Rubinsztein earned his MB ChB, BSc(Med), and PhD degrees from University of Cape Town. He came to Cambridge in 1993 as a Senior Registrar in genetic pathology. His research is focused in the field of autophagy, particularly in the context of neurodegenerative diseases. His laboratory has pursued the strategy of autophagy upregulation as a possible therapeutic approach in various neurodegenerative diseases and has identified drugs and novel pathways that may be exploited for this objective. He has made contributions that reveal the relevance of autophagy defects as a disease mechanism and to the basic cell biology of this important catabolic process. Rubinsztein was elected Fellow of the Academy of Medical Sciences (2004), EMBO member (2011), Fellow of the Royal Society (2017), and member of Academia Europaea (2022). He was awarded the Graham Bull Prize (2007), Thudichum Medal (2017), Roger de Spoelberch prize (2017) and the Goudie Medal (2020). He was identified as a Clarivates Analytics Highly Cited Researcher (2018, 2019, 2020,2021).

Hans Aerts

Hans Aerts

Leiden University, Netherlands

Professor Hans Aerts chairs the Department of Medical Biochemistry at Leiden University. Earlier he chaired the Department of Biochemistry at the Academic Medical Center in Amsterdam (2000-2014). His research focuses on glycosphingolipids in health and disease with special attention for inherited lysosomal storage disorders like Gaucher disease, as well as neurodegeneration and the Metabolic Syndrome.
Trained in biochemistry at the University of Amsterdam (Prof. Joseph Tager) and the National Institutes of Health in Bethesda, USA, he completed his PhD thesis Biochemical studies on glucocerebrosidase in relation to Gaucher disease with honours in 1988. He was involved in the first application of enzyme replacement therapy and substrate reduction therapy of type 1 Gaucher disease in Europe as well as the discovery of now widely used biomarkers. He has been (co)promotor of 44 completed PhD thesis works and published over 400 peer-reviewed papers (H-index: 94, Google Scholar).
Professor Aerts is recipient of various governmental research grants, including the ERC Advanced Research Grant ‘Chemical Biology of Sphingolipids and the NWO Building Blocks of Life Grant ‘Glucosylceramide’. He is co-founder and honorary president of the European Working Group on Gaucher Disease (EWGGD), a society comprising all major Gaucher clinical and research centres and national patient societies worldwide..

ESGLD Virtual Summer Meeting 2021 – Programme

Please note ALL times are UK time (BST)

Day 1  Thursday 8th September

14:00 – 18:00 Registration
18:00 – 18:15 Opening Ceremony – Welcome Address
18:15 – 18:30 Flash talk awards
18:30 – 19:30 KEYNOTE SPEAKER 1 Professor Simon Jones, Manchester University Hospitals NHS Foundation Trust, UK
19:30 – 20:00 BREAK
20:00 onwards Get together and dinner

Day 2   Tuesday 29th June

Lysosomal Function

Session 1 (Chair Andrea Ballabio)

12pm (BST)/1pm (CEST)   Keynote speakerJuan Bonifacino - NIH, Bethesda, USA

Molecular mechanisms of lysosome positioning

Bright ideas/flash talks

12.35pm (BST)/1.35pm (CEST)   S.L.M. in 't GroenUncovering pathological mechanisms in Pompe disease using a 3D-skeletal-muscle-on-a-chip system.

12.40pm (BST)/1.40pm (CEST)    Mara Reichmann - Loss of TMEM55B leads to subfertility in male mice

12.45pm (BST)/1.45pm (CEST)   Florian Bleimbaum - Co-expression network analysis identifies NHLRC3 as a new lysosomal protein to control endothelial cell homeostasis

12.50pm (BST)/1.50pm (CEST)   Tereza Andreou - Brain-targeted Haematopoietic Stem Cell Gene Therapy for severe Mucopolysaccharidosis I (Hurler) - does one peptide tag fit all?

12.55pm (BST)/1.55pm (CEST)    Jane Potter - Ex-vivo autologous haematopoietic stem cell gene therapy in mucopolysaccharidosis type IIIA

1pm (BST)/2pm (CEST)               Q&A group discussion (Chair Andrea Ballabio)

1.20pm (BST)/2.20pm (CEST)     Coffee break

Session 2 (Chair Mia Horowitz)

1.40pm (BST)/2.40pm (CEST)     Invited speakerChiara di Malta - TIGEM, Naples, Italy - Transcriptional regulation of mTORC1 signaling in physiology and cancer

2.15pm (BST)/3.15pm (CEST)     M Klussendorf - Cytoplasmic retention of acetylated transcription factor EB

2.35pm (BST)/3.35pm (CEST)     Sonke Rudnik - S-palmitoylation determines TMEM55B-dependent positioning of lysosomes

2.55pm (BST)/3.55pm (CEST)     Coffee break

Session 3 (Chair Thomas Braulke)

3.15pm (BST)/4.15pm (CEST)     Invited speaker - James H. Hurley - University of California, Berkley, USA - Coordination of the Rag GTPase cycle on lysosomes

3.50pm (BST)/4.50pm (CEST)     Dominic Winter - Characterization of Lysosomal Protein Interactions and Structures by Cross Linking Mass Spectrometry

4.10pm (BST)/5.10pm (CEST)     Shroddha Bose - Impact of altered chloride transport on lysosomal morphology and function

4.30pm (BST)/5.30pm (CEST)     Group discussion on lysosomal function (Chaired by Andrea Ballabio and Including Invited speakers from the day)

5.00pm (BST)/6.00pm (CEST)      Day 2 main conference closes

5 – 5.30pm (BST)/6 – 6.30pm (CEST) Day 2 - Zoom Drinks Reception (Everyone Welcome - Bring Your Own Beer!) Meeting ID will follow

Day 3    Wednesday 30th June

Therapies and diagnosis

Session 1 (Chair Francisca Coutinho)

12pm (BST)/1pm (CEST)             Invited speaker - Sandra Alves - Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA), Portugal - Oligonucleotide-based therapies for inherited metabolic diseases: some examples of their application in Lysosomal Storage Disorders.

12.35pm (BST)/1.35pm (CEST)    Xuefang Pan - Oral Glucosamine Ameliorates Aggravated Neurological Phenotype in Mucopolysaccharidosis III Type C Mouse Model Expressing Misfolded HGSNAT Variant

12.55pm (BST)/1.55pm (CEST)    Atze BergsmaIdentification of aberrant splicing events that induce nonsense-mediated decay and development of splice switching antisense oligonucleotides for Pompe disease

1.15pm (BST)/2.15pm (CEST)    Coffee break


Session 2 (Chair Pim Pijnappel)

1.35pm (BST)/2.35pm (CEST)      Invited speaker - Federico Mingozzi - Spark Therapeutics, Philadelphia, USA - Targeting the liver to develop in vivo gene therapies for lysosomal storage diseases

2.10pm (BST)/3.10pm (CEST)      Alessandro di Spiezio - Enzyme replacement therapy with pro cathepsin D in NCL disease

2.30pm (BST)/3.30pm (CEST)      Valeria De Pasquale - Targeting heparin sulfate proteoglycans as a novel treatment for neuropathology in Mucopolysaccharidosis IIIB

2.50pm (BST)/3.50pm (CEST)    Coffee break

Session 3 (Chair Brian Bigger)

3.10pm (BST)/4.10pm (CEST)      Invited speaker - Eric Adler - UC San Diego, La Jolla, USA - New Therapy for Danon Disease (TBC)

3.45pm (BST)/4.45pm (CEST)      Shaun Wood - Long-term Outcomes of Brain-targeted Haematopoietic Stem Cell Gene Therapy for Mucopolysaccharidosis Type II in Pre-Clinical MPSII Mouse Model

4.05pm (BST)/5.05pm (CEST)      Nicola BrunettiSafety and efficacy of liver-directed AAV-mediated gene therapy for mucopolysaccharidosis type VI

4.25pm (BST)/5.25pm (CEST)      Group discussion on therapies and diagnosis (Chaired by Brian Bigger and Including Invited speakers from the day)

4.45pm (BST)/5.45pm (CEST)    Coffee break

4.55pm (BST)/5.55pm (CEST)      Award for best presentation

5pm(BST)/6pm (CEST)                Award for best flash talk

5.05pm (BST)/6.05pm (CEST)    Concluding remarks

5.10pm (BST)/6.10pm (CEST)      Conference close

ESGLD 2021 Faculty

Brian Bigger

Brian Bigger

ESGLD Chairman, UoM, Manchester, UK

Brian Bigger was awarded a Bachelors degree from the University of Bath in Applied Biology. His PhD was conducted in the Gene Therapy Research Group, Imperial College, London, where he worked with Professor Charles Coutelle on developing a gene delivery vehicle for mitochondrial gene therapy. On completion of his PhD in 2000, Dr Bigger joined Dr Mike Themis, Imperial College, London to work on a Wellcome Trust collaborative project with Cancer Research UK, investigating gene delivery to stem cells for liver diseases. In 2004 he joined Dr Suzanne Watt’s group in Oxford University and the National Blood Service as a Senior Research Scientist to work on mechanisms of stem cell homing. In 2006 Dr Bigger set up the Stem Cell & Neurotherapies laboratory at the University of Manchester and the Royal Manchester Children’s hospital.

Carmine Settembre

Carmine Settembre

TIGEM, Naples, Italy

Dr. Carmine Settembre graduated in 2002 in pharmaceutical chemistry at the university of Naples “Federico II”. In 2002 he joined TIGEM institute as PhD student, then he moved in the United States as post-doctoral fellow first at Columbia University in New York and then at the Baylor College of Medicine, in Houston.  In 2011 he became assistant professor at the Baylor college of medicine. In 2013, thanks to the Dulbecco Telethon Institute (DTI) career award program he set up his own laboratory at TIGEM. In 2018 he became associate professor in Histology and Embryology at the University of Naples “Federico II”.

Judith Klumperman

Judith Klumperman

UMC Utrecht, Utrecht, Netherlands

Judith Klumperman is since 2001 professor of Cell Biology at the University Medical Centre Utrecht in The Netherlands. Her lab is widely recognized as expertise centre for electron microscopy (EM), especially immuno-EM and correlative microscopy (CLEM). By CLEM, molecular, dynamic and functional information from light or live cell microscopy is directly correlated to EM images. Judith’s current research focuses on the role of tethering complexes in lysosome biogenesis and the role of lysosomes in cancer and neurodegenerative diseases. Judith is chair of the national Netherlands Electron Microscopy Infrastructure.

Christian Haass

Christian Haass

LMU Munich DZNE, Munich, Germany

Christian Haass graduated in Molecular Biology at the University of Heidelberg, Germany. He was a postdoc and Assistant professor of Neurology at the Harvard Medical School in the Institute of Dr. Dennis Selkoe. Since 1999 he is the head of the division of Biochemistry at the Ludwig-Maximilians University. Haass is also the coordinator of the German Center for Neurodegenerative Disorders (DZNE) in Munich and the speaker of the DFG cluster of excellence “Systems Neurology (SyNergy)”. Haass received many awards, among them the Brain Prize in 2018.

Juan Bonifacino

Juan Bonifacino

NIH, Bethesda, USA

Dr. Juan S. Bonifacino is a National Institutes of Health (NIH) Distinguished Investigator and Associate Scientific Director for the Neuroscience and Cellular and Structural Biology Division (NCSBD) of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH. Bethesda, Maryland, USA. His laboratory studies the molecular mechanisms of intracellular protein and organelle transport, and the diseases that result from dysfunction of these mechanisms.

Chiara di Malta

Chiara di Malta

TIGEM, Naples, Italy

I graduated in 2005 at the University of Naples Federico II. Then I joined the TIGEM as an Open University PhD student, in Andrea Ballabio’s laboratory. My main PhD research project was focused to the study of the mechanisms leading to the neurodegeneration in lysosomal storage disorders (LSDs). I spent more than three years in the United States where I worked at Baylor College of Medicine (Houston) as visiting PhD student. During this period, I also contributed to the identification of the Transcription factor EB (TFEB) as a master regulator of lysosome biogenesis and autophagy. As postdoctoral researcher I discovered a new transcriptional regulation, mediated by TFEB, controlling mTORC1 signaling in response to nutrients. More recently, I demonstrated that this mechanism promotes cystogenesis and tumor growth in Birt-Hogg-Dube’ syndrome, a genetic condition due to loss of function mutations in the gene encoding FLCN, a key player of mTORC1 signaling. I’m an independent investigator at Tigem since January 2021. My research activity is currently supported by Kidney Cancer Association, Worldwide Cancer Research and Telethon foundation.

James H. Hurley

James H. Hurley

University of California, Berkley, USA

James (“Jim”) Hurley is a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. He graduated in Physics from San Francisco State University and obtained his Ph.D. in Biophysics in 1990 from the University of California, San Francisco. He was a senior investigator in the intramural program of the National Institutes of Health from 1992-2013, and joined the faculty of the University of California, Berkeley in 2013. He is a member of the National Academy of Sciences.

Dr. Hurley uses structural biology, biophysics, biochemistry, and cell biology approaches to understand the structure and function of cell membranes in health and disease. He is known for his work on the structure and mechanism of the ESCRT membrane scission machinery, coated vesicle and endosome biogenesis, lipid transporters and second messenger systems, and the autophagy core complexes.

Dr. Hurley’s lab currently has four major projects in the general area of mechanistic membrane biology. He has a long-standing interest in the core mechanisms of autophagy, and is currently focusing on the structural and biophysical basis of mitophagy and its role in Parkinson’s Disease. He is investigating the mechanism of membrane scission by ESCRT complexes in the contexts of HIV budding and release from infected cells, autophagy, and membrane repair. In a third project, the hijacking of coated vesicle trafficking by HIV is being worked out by structural, reconstitution, and live cell imaging approaches. Lastly, in the newest project, he is using structural and biochemical approaches to study the roles of the lysosomal GTPase regulatory complexes FLCN-FNIP and C9orf72-SMRC8 in neurodegenerative diseases.

Sandra Alves

Sandra Alves

Sandra Alves

PhD in Molecular Biology in 2002 at Faculty of Sciences of the University of Porto. Auxiliary Researcher in the Department of Human Genetics in the Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA) and Head of the Lysosomal Storage Diseases Research Group.
Her scientific activity has been developed in the Human Genetics field with a major focus on LSDs. She has been conducting studies in order to expand the knowledge on the mutational spectrum of these diseases in Portugal. Mucolipidoses (ML) and mucopolysaccharidoses (MPS) are her major research focus. Presently, her group aims to develop RNA based therapeutic approaches to address these pathologies. The correction of LSDs causing mutations and the decrease of accumulated substrates are some of examples of aims that drive the development of such approaches.

Federico Mingozzi

Federico Mingozzi

Spark Therapeutics, Philadelphia, USA

Dr. Federico Mingozzi is the chief scientific officer at Spark Therapeutics, bringing two decades of experience in gene therapy, immunology, as well as biochemistry and molecular biology in both industry and academic settings.

Federico began his scientific career studying the genetic basis of bleeding disorders. At the Children’s Hospital Philadelphia (CHOP) he conducted pioneering studies on liver gene transfer with adeno-associated virus (AAV) vectors and immunology. Federico was involved in several first-in-human clinical studies of gene therapy based on the AAV vector platform while serving as the director of translational research the Center for Cellular and Molecular Therapeutics, at CHOP. He also led studies aimed at the characterization of human immune responses to AAV vectors and the development of strategies to modulate vector immunogenicity.

Eric Adler

Eric Adler

UC San Diego, La Jolla, USA

Eric Adler, MD, is a Professor of Medicine and Medical Director of the Heart Transplant Program at the University of California, San Diego (UCSD). He earned his medical degree from Boston University School of Medicine. He completed his internship and residency at the University of Washington and a cardiology fellowship at Mount Sinai School of Medicine. He is board certified in cardiovascular disease and advanced heart failure. He specializes in caring for patients with advanced heart failure, including those who need ventricular assist devices (VADs) or heart transplants.

His research is focsed on the study and treatment of cardiomyopathy. He has contributed to multipe papers demonstrating techniques for the isolation of enriched populations of cardiovascular progenitor cells from pluripotent stem cells and the utility of these cells for modeling cardiovascular disease. Recently, his work has led to the development of a novel gene therapy for Danon disease, a rare cardiovascular disorder associated with severe hypertrophic cardiomyopathy. The treatment is currently being evaluated in a Phase 1 trial. He also performs clinical research in heart failure and have high-impact publications on a variety of topics including cardiac transplant, mechanical circulatory support, palliative care and machine learning.

Contact ESGLD

For further information please contact:
Prof. Dr. Paul Saftig
Biochemisches Institut
CAU Kiel
Olshausenstr. 40
D-24098 Kiel
Tel: ++ 49-(0)431-8802216

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